Low Testosterone Linked to Alzheimer’s and Early Death

Hormone balance is not confined to women but somehow men don’t get the same level of attention. This may be because they do not pay as much attention to their own health, or visit the doctor as often, so this is aimed as much at the women in their life as it is at them. This is an alert to prompt men to get their testosterone levels checked because of the new links between that and Alzheimer’s and even premature death.

Alzheimer’s
This new research on Alzheimer’s comes from a team that was led by Leung-Wing Chu, M.D., Chief of the Division of Geriatric Medicine at Queen Mary Hospital at the University of Hong Kong. The researchers studied 153 Chinese men who were at least 55 years and older, lived in the community and didn’t have dementia. Of those men, 47 had mild cognitive impairment — or problems with clear thinking and memory loss.

Within a year, 10 men who all were part of the cognitively impaired group developed probable Alzheimer’s disease. They also had low testosterone; elevated levels of the ApoE 4 (apolipoprotein E) protein, which is correlated with a higher risk of Alzheimer’s disease; and high blood pressure. Going a step further, the research indicates that having good levels of testosterone may also have a protective value against the disease.

Low Testosterone Linked to Greater Risk of Early Death
A report in the BMJ-British Medical Journal this month also reported that low testosterone levels seem to be linked to a heightened risk of premature death from heart disease and all causes.

This research is based on 930 men, all of whom had coronary artery heart disease, and had been referred to a specialist heart centre between 2000 and 2002. Their heart health was then tracked for around 7 years.

On referral, low testosterone was relatively common. One in four of the men was classified as having low testosterone, as opposed to a tailing off in levels of the hormone as a result of ageing. During the monitoring period almost twice as many men with low testosterone died as did those with normal levels.

The only factors that influenced this risk were heart failure, treatment with aspirin or a high blood pressure drug and low bio-T levels. A low bio-T level was an independent risk factor for premature death from all causes and from heart disease, after taking account of other influential factors, such as age, other underlying health problems, smoking and weight.

It is not just low levels that are a problem either, as borderline levels of low total testosterone also increased the risk of an early death. Low levels are associated with obesity, risky blood fats, and insulin resistance, all of which are themselves risk factors for diabetes and heart disease.

Time for a visit to the doctor?

Natural Help for Memory Loss

We all forget where we put things, or the name of someone familiar can’t be recalled, and losing one’s memory is a major fear as we get older. Fortunately, there are a number of things can do to keep your memory sharp and active. There are plenty of ideas here from new supplements to tried and tested memory boosters so try them out and see what works for you.

There are supplements that can help to boost your brain power and Ginkgo biloba tincture has been proven in research to help in the treatment of Alzheimer’s and dementia. In one study, of those taking the leaf extract, 27 percent maintained cognitive functioning and memory, while 86 percent of the placebo group lost functioning BUT if you are taking a daily aspirin (though this is now no longer recommended) to avoid a stroke or heart attack then please be aware that the blood-thinning effects of aspirin are increased by ginkgo.

Something else that can prove useful is a remarkable brain cell nutrient called phosphatidylserine. This is a phospholipid found in all cells of the human body with higher concentrations in the brain cell membrane and its importance as a nutrient for the brain has been clinically proven. It forms a major constituent of brain and nerve cells and is essential for neuronal signalling and is a natural component of our diet in varying levels. As we get older, changes in the composition of these cells in the part of the brain called the hippocampus, lead to a reduction in the amount of information we can store and consequent memory loss. Clinical studies over a period of 20 years have shown that regular supplementation with phosphatidylserine restores and maintains adequate nerve cell function in a variety of ways which leads to improvements in long term memory and long term recognition.

If this sounds like something of interest to you, then I have been taking a supplement called memory lane which contains phosphatidylserine and, although I am still assessing the benefits, I think it does seem to be helping. Benefits that are associated with phosphatidylserine are enhanced memory, concentration and learning and in this particular formulation the phosphatidylserine is derived from soy (non GMO), so is guaranteed BSE free. The safety of PS supplementation is well documented and there have been no reports of adverse interaction with other medications.

If you are looking for some additional ways to help your memory than I can certainly recommend daily meditation is again it has been proven to help. Even five minutes a day will make a difference.

If you are not already a fan of any form of puzzle — crosswords, jigsaws, Suduko or anything else – then make a start now. Mental workouts and stimulus of vital aspects of keeping your brain active and encouraging memory. Go back to the old childhood game of memorising a number of objects on a tray or pick a favourite poem and learn it by heart until you can recite it without prompting. Doesn’t matter what you do, just do something every day that tickles your brain into action.

If you are suffering from high blood pressure then do your very best to lower it through diet and exercise as again it has been proven that lowering your blood pressure will improve your memory.

How to reduce your risk of Alzheimer’s

I am always in favour of prevention rather than cure and there is now significant evidence that lifestyle and diet may play a role in reducing your risk of developing this increasingly common condition. Just as a heart-healthy diet reduces your risk of heart disease, a similar diet seems to also contribute to Alzheimer’s prevention by reducing some risks. The same medical conditions (diabetes, high blood pressure, high cholesterol) and lifestyle factors (lack of exercise, poor diet, smoking, obesity) that lead to stroke and heart disease also lead to a higher risk of developing Alzheimer’s disease. This is because the factors that affect blood vessels throughout the body also affect blood vessels in the brain.

In the latest study, published in April 2010, over 2,000 elderly New Yorkers who were dementia free were followed for almost 4 years. In that time, 253 subjects developed Alzheimer’s disease, and the dietary patterns of all subjects were characterized and analyzed. They don’t say at what point elderly begins, but I will be generous and assume that all their subjects were over the age of 60, but the common characteristics of a ‘brain-healthy’ diet generally avoids saturated fats and cholesterol, and emphasizes dark-skinned fruits and vegetables (rich in anti-oxidants) and coldwater fish (which contain omega-3 fatty acids).

The study found that those people who strongly adhered to this dietary pattern were 38% less likely to develop Alzheimer’s disease compared with those whose diet was significantly different.

If you want to minimise your risk of developing Alzheimer’s than basically you need to follow a modified Mediterranean diet. This means higher intakes of nuts, fish, tomatoes, poultry, cruciferous vegetables, fruits, salad dressing (oil and vinegar) and dark green leafy vegetables and a lower intake of high-fat dairy products, red meat, organ meat, and butter.

A previous study published in 2006, showed that people who most closely followed the Mediterranean diet had the lowest Alzheimer’s risk – 40% lower than those who were least likely to follow the diet. This diet places emphasis on eating fruits, vegetables, nuts, beans and grains with red meat and poultry eaten only rarely, and olive oil and fatty fish are the main sources of fat in the diet.

I think this is good news as once again it puts responsibility for our long-term health into our own hands — and hence into our stomachs. We have absolutely no control over our genetic inheritance or predisposition to certain diseases, but what we certainly can do is create the best conditions for optimal health through a health promoting — not health debilitating — diet.

Vitamin D and Alzheimer’s link confirmed

Cambridge University and the University of Michigan, have for the first time identified a relationship between Vitamin D and cognitive impairment in a large-scale study of older people. In northern climates there can be a lack of vitamin D, particularly in the winter months, when we suffer from grey skies and not enough sunshine.

Vitamin D is vital to our immune system and to keep our bones strong in the process of breaking down old bone and building up new bone. This process goes on throughout out lives, but it can slow down without the right levels of vitamin and mineral support. We obtain our supply from sunlight, foods fortified with vitamin D like cow’s milk, soya milk and cereals and oily fish. Unfortunately, as we get older we are less able to absorb vitamin D from sunlight so need to increase our intake from other sources or take supplements.

This new study is important because it reinforces the connection between vitamin D, cognitive function and dementia as in Alzheimer’s. The researchers assessed cognitive function in 2000 adults aged 65 and over in England, and what they found was that as levels of Vitamin D went down, their levels of cognitive impairment went up. In fact they had double the chance of being cognitively impaired than those in the study who had good levels of vitamin D.

As prevention is infinitely better than cure – which, sadly, in the case of Alzheimer’s is still being sought – it makes sense to do all you can to weigh the odds in your favour. Keep mentally alert with quizzes, crosswords or bridge. Take up a new hobby that stretches your brain (line or sequence dancing works well for this) and think about learning a new language or skill. Book a holiday in the sun in the winter and sensibly enjoy exposure to sunlight as often as you can. Supplements are easy to obtain, but there are cautions with them so don’t exceed the dose recommended by your doctor or a qualified nutritionist.

Want to boost your IQ

Exercise is the keystone for healthy living, but it is not often advocated to help you to boost your IQ. We already know that older people who exercise three or more times a week have a significantly reduced risk of developing Alzheimer’s and other types of dementia. Whatever your age, if you exercise regularly you have a 30 to 40 percent lower risk of dementia, and even as little as 15 minutes of exercise, three days a week, cuts your risk significantly. One short, brisk, walk every day can make a real difference, but what is new is that recent studies have shown that some forms of exercise may actually help you think better, while others have little or no impact on your brain matter. Here’s three suggestions for what works, and what doesn’t, for those ‘little grey cells’.

Aerobic Training:
In 2006, Arthur Kramer of the University of Illinois used MRIs to prove that aerobic exercise builds grey and white matter in the brains of older adults. Later studies found that more aerobically fit schoolkids also perform better on cognitive tests. Widely accepted now that aerobic exercise is one of the best things you can do to stay mentally agile into old age.
Impact on intelligence: STRONG

Weight Training:
It might make you feel good to have ripped muscles, but researchers have found only the most tenuous link between heavy resistance training and improved cognitive function.
Impact on intelligence: NEGLIBIBLE

Yoga:
You need as much oxygen as you can get, particularly for brain function, but under stress we tend to hold our breath and reduce our intake which can certainly affect our memory. Yoga can break that habit by helping you learn to breathe correctly which results in less stress and more oxygen.
Impact on intelligence: POSSIBLY STRONG