How to reduce your risk of Alzheimer’s

I am always in favour of prevention rather than cure and there is now significant evidence that lifestyle and diet may play a role in reducing your risk of developing this increasingly common condition. Just as a heart-healthy diet reduces your risk of heart disease, a similar diet seems to also contribute to Alzheimer’s prevention by reducing some risks. The same medical conditions (diabetes, high blood pressure, high cholesterol) and lifestyle factors (lack of exercise, poor diet, smoking, obesity) that lead to stroke and heart disease also lead to a higher risk of developing Alzheimer’s disease. This is because the factors that affect blood vessels throughout the body also affect blood vessels in the brain.

In the latest study, published in April 2010, over 2,000 elderly New Yorkers who were dementia free were followed for almost 4 years. In that time, 253 subjects developed Alzheimer’s disease, and the dietary patterns of all subjects were characterized and analyzed. They don’t say at what point elderly begins, but I will be generous and assume that all their subjects were over the age of 60, but the common characteristics of a ‘brain-healthy’ diet generally avoids saturated fats and cholesterol, and emphasizes dark-skinned fruits and vegetables (rich in anti-oxidants) and coldwater fish (which contain omega-3 fatty acids).

The study found that those people who strongly adhered to this dietary pattern were 38% less likely to develop Alzheimer’s disease compared with those whose diet was significantly different.

If you want to minimise your risk of developing Alzheimer’s than basically you need to follow a modified Mediterranean diet. This means higher intakes of nuts, fish, tomatoes, poultry, cruciferous vegetables, fruits, salad dressing (oil and vinegar) and dark green leafy vegetables and a lower intake of high-fat dairy products, red meat, organ meat, and butter.

A previous study published in 2006, showed that people who most closely followed the Mediterranean diet had the lowest Alzheimer’s risk – 40% lower than those who were least likely to follow the diet. This diet places emphasis on eating fruits, vegetables, nuts, beans and grains with red meat and poultry eaten only rarely, and olive oil and fatty fish are the main sources of fat in the diet.

I think this is good news as once again it puts responsibility for our long-term health into our own hands — and hence into our stomachs. We have absolutely no control over our genetic inheritance or predisposition to certain diseases, but what we certainly can do is create the best conditions for optimal health through a health promoting — not health debilitating — diet.

Alzheimers detection in young people is possible

Alzheimer’s is one of society’s greatest fears, and although this item has been covered this week in the mainstream press I just wanted to highlight in case you missed it. It seems it may now be possible to have an early diagnostic test in teenagers to establish their risk for the disease as scans have found that people carrying the affected gene show changes in their brain activity decades before any symptoms from dementia might occur.

This gene is responsible for removing cholesterol from the blood and taking it to the liver where it is broken down and is involved in brain function and repair. The APOE4 version of the gene has also been linked with a higher risk of cardiovascular disease and poor recovery from traumatic brain injuries. People who inherit one copy of the APOE4 gene are known to be at a four fold increased risk of Alzheimer’s disease while those with two copies are at ten times the normal risk. One in four of the population are though to have at least one copy of the gene, although even those who carry the altered gene are not certain to go on to have symptoms of dementia and those without the gene are not completely in the clear. A team at University of Oxford and Imperial College London carried out a series of brain scans on people aged between 20 and 35 who were showing no signs of the disease but were carrying the altered gene and compared the results to people with a different version of the gene. These results are the first to show that there was hyperactivity in the part of the brain involved in memory in healthy young people who have the APOE4 version of the gene. The study shows that their brains behave differently even when they are not asked to perform memory tests. It is thought the brains of people carrying the APOE4 version of the gene have to work harder both during memory tests and at rest and become ‘worn out’ which is what brings on symptoms of dementia later in life.

These are exciting first steps towards establishing a diagnostic procedure much earlier to show who may go on to develop Alzheimer’s and hopefully aid in prevention and treatment. Further news in this week is that the already popular Mediterranean diet might also significantly decrease the risk of Alzheimer’s disease and other forms of dementia, according to a study from the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain at Columbia University.

A third of participants who strictly followed a Mediterranean diet were 28 percent less likely to develop borderline dementia than the third with the lowest adherence; and the diet also appeared to protect patients with borderline dementia from developing Alzheimer’s disease. Again, the ones with the highest adherence to the diet were 48 percent less likely to develop Alzheimer’s than the one-third with the lowest compliance. So get out the olive oil and increase the amount of vegetables, fish and pulses and decrease the saturated fats, dairy and red meat.

Blood test to detect early Alzheimer’s

There is no doubt that the fear of Alzheimer’s is a major concern for many people as they get older. A natural, and normal slight memory loss – those ‘senior moments’ – can develop into a genuine worry about the development of the disease. Part of the problem has been that there is no foolproof way of predicting who is vulnerable, no reliable test, or how to spot the disease in its very early stages. Now there may be a way to overcome this through a simple blood test.

Scientists at a California biotech company claim that the test is about 90% accurate and can detect Alzheimer’s two to six years before the onset of symptoms. It works through the signals the brain sends to the body’s immune system. These signals pick up changes in the blood proteins in the brain and certain changes in these proteins produce a pattern that’s characteristic to Alzheimer’s.

There are more than 100 different types of dementia, but Alzheimer’s is the most common and there are 417,000 people diagnosed with it in the UK – predicted to rise to over 1 million by 2025.

It will be a few years before this test is available for use by doctors and it would be offered first to those whose close relatives have the disease and who may be suffering memory loss themselves. It may be that you don’t want to know in advance if you have this disease, but an early diagnosis can give patients a chance to make changes to their diet and exercise more in an effort of slowing or staving off chances of getting the disease.

SELF HELP PROGRAMME
Despite common belief, heredity only plays a part in getting Alzheimer’s and it is more likely that environmental factors play a part – particularly the role of free radicals as they cause damage to cells. Cortisol, a stress hormone, may be a causative factor, particularly when produced over a long period of time and good nutrition and herbal treatments prevent and fight damage from free radicals and reduce stress. Toxins such as aluminium and mercury are also a problem since they can be taken into the body and remain in the tissues.

There are a number of things you can do to help lessen some of the symptoms, or the onset, of Alzheimer’s and these are just a few of the supplements that have been found to be effective in many cases:

*Ginkgo biloba for improved memory, attention and mood.

*B vitamins, particularly Folate, which is important to the nervous system and helps eliminate homocysteine from the blood.

*Vitamin E is a scavenger of free radicals and it is fat soluble so readily enters the brain where it is thought to slow cell damage.

*The Ayuredic herb Ashwagandha (Withania somniferum) is used as a brain tonic and reduces stress hormone levels

*DHEA is a hormone used to help cognitive function

*Chlorella aids in the detoxification process of heavy metals.

For more information on Alzheimer’s and dementia, visit www.alzheimers.org.uk